43 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipIndependence
DepartsFri, May 7th 2027
ReturnsSat, Jun 19th 2027
Nights43
Departing PortTampa
Ports of CallTampa (2 Days), Punta Gorda, Marco Island, Key West (2 Days), Key Biscayne, West Palm Beach, Port Canaveral, Green Cove Springs, Saint Augustine, Sailing Tolomato River, Amelia Island (2 Days), Jekyll Island, St. Simons Island, Savannah, Hilton Head Island, Beaufort, Charleston, East Coast Inland Passage, Wilmington, Beaufort, Morehead, Kitty Hawk, Norfolk, St. Michaels, Washington, D.C., Boston, Portland (ME), Bath, Boothbay Harbor, Bar Harbor, Bangor, Maine, Rockland, Camden, Portsmouth, Gloucester, Provincetown, Newport, Martha's Vineyard, Massachusetts (2 Days), Nantucket, Plymouth, Boston
The Independence is equipped with the largest staterooms in the industry with most suites featuring private balconies. With the latest in navigation and safety technology, the Independence is fully stabilized, allowing American Cruise … 
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7 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipIndependence
DepartsSat, May 15th 2027
ReturnsSat, May 22nd 2027
Nights7
Departing PortBaltimore
Ports of CallBaltimore, Annapolis, St. Michaels, Cambridge, Chesapeake/Delaware Canal, Williamsburg, Mount Vernon, Washington, D.C.
The Independence is equipped with the largest staterooms in the industry with most suites featuring private balconies. With the latest in navigation and safety technology, the Independence is fully stabilized, allowing American Cruise …
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Outside
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7 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipIndependence
DepartsSat, May 22nd 2027
ReturnsSat, May 29th 2027
Nights7
Departing PortWashington, D.C.
Ports of CallWashington, D.C., Williamsburg, Chesapeake/Delaware Canal, Cambridge, St. Michaels, Annapolis, Baltimore (2 Days)
The Independence is equipped with the largest staterooms in the industry with most suites featuring private balconies. With the latest in navigation and safety technology, the Independence is fully stabilized, allowing American Cruise …
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Outside
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Balcony
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50 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipIndependence
DepartsFri, May 28th 2027
ReturnsSat, Jul 17th 2027
Nights50
Departing PortPortland (OR)
Ports of CallPortland (OR) (2 Days), Cruise The Columbia River, Astoria, Kalama, Washington, The Dalles, Columbia River, Richland, Snake River, Clarkston, Kalispell, Coeur d'Alene, Glacier National Park, Butte, Yellowstone National Park (3 Days), Jackson (2 Days), New Orleans, Oak Alley, Baton Rouge, St. Francisville, Natchez, Vicksburg, Greenville, Tunica, Memphis, Mississippi River, Cape Girardeau, Mississippi River, St Louis, Mississippi River, Hannibal, Mississippi River, Muscatine, Dubuque, Cruising the River, Winona, Red Wing, Minneapolis/St. Paul, Boston, Portland (ME), Bath, Boothbay Harbor, Bar Harbor, Bangor, Maine, Rockland, Camden, Portsmouth, Gloucester, Provincetown, Newport, Martha's Vineyard, Massachusetts, Nantucket, Plymouth, Boston
The Independence is equipped with the largest staterooms in the industry with most suites featuring private balconies. With the latest in navigation and safety technology, the Independence is fully stabilized, allowing American Cruise …
Inside Cabin
Call for pricing
Outside
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Balcony
Call for pricing
Suite
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Prices are per person, double occupancy, cruise only and on select sailings. Prices shown are for stateroom categories as noted and are shown in US Dollars. Pricing listed includes taxes and fees. Airfare is not included. Prices and itineraries are based on availability and are subject to change without notice.
